Insulitis and Diabetes: A Perspective on Islet Inflammation
نویسندگان
چکیده
منابع مشابه
Protection of nonobese diabetic mice from autoimmune diabetes by reduction of islet mass before insulitis.
Nonobese diabetic mice spontaneously develop diabetes that is caused by autoimmune cell-mediated destruction of pancreatic beta cells. Here we report that surgical removal of 90% of pancreatic tissue before onset of insulitis induced a long-term diabetes-free condition in nonobese diabetic mice. Pancreatectomy after development of moderate insulitis had no effect on the course of diabetes. The ...
متن کاملLymphangiogenesis Is Required for Pancreatic Islet Inflammation and Diabetes
Lymphangiogenesis is a common phenomenon observed during inflammation and engraftment of transplants, but its precise role in the immune response and underlying mechanisms of regulation remain poorly defined. Here we showed that in response to injury and autoimmunity, lymphangiogenesis occurred around islets and played a key role in the islet inflammation in mice. Vascular endothelial growth fa...
متن کاملIslet inflammation in type 2 diabetes and physiology.
The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell dysfunction has further highlighted the significance of inflammation in metabolic diseases. The number of intra-islet macrophages is increased in T2D, and these cells are the main source of proinflammatory cytokines within islets. Multiple human studies of T2D have shown that targeting islet inflammation ha...
متن کاملIslet inflammation in type 2 diabetes and physiology
Introduction Metabolic syndrome comprises a cluster of diseases associated with excess nutrition and insufficient physical activity. Studies over the last two decades have shown that chronic inflammation is a common and potentially unifying mechanistic cause of these diseases (1–4). Inflammation can be viewed as an evolutionarily selected protective response enabling the host organism to cope w...
متن کاملa head parameter survey on mazandarani dialect and its effect(s) on learning english from ca perspective (on the basis of x-bar syntax)1
there has been a gradual shift of focus from the study of rule systems, which have increasingly been regarded as impoverished, … to the study of systems of principles, which appear to occupy a much more central position in determining the character and variety of possible human languages. there is a set of absolute universals, notions and principles existing in ug which do not vary from one ...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Immunome Research
سال: 2014
ISSN: 1745-7580
DOI: 10.4172/1745-7580.s2.e002